Cook pasta
Bring a large pot of salted water to a boil. Cook macaroni until just al dente. Drain and set aside.
Make the roux
In a large saucepan, melt butter over medium heat. Whisk in flour and cook for 1–2 minutes until smooth and lightly golden.
Build the sauce
Slowly whisk in milk and heavy cream. Continue whisking until the sauce thickens and becomes smooth.
Season
Stir in Dijon mustard, garlic powder, salt, and pepper.
Add the cheese
Reduce heat to low and add cheddar, Gruyère, and parmesan. Stir until fully melted and creamy.
Combine
Add cooked pasta to the sauce and stir until evenly coated.
Assemble
Pour into a greased baking dish.
Make topping
Mix panko, melted butter, and parmesan. Sprinkle evenly over the top.
Bake
Bake at 375°F for 20–25 minutes until hot, bubbly, and golden brown.